詳細介紹
37215壓力測試儀是經典的7200 paw壓力測試儀的升級產品自1965年使用以來該測試儀在多個學術和工業實驗室為鎮痛藥物的開發和研究做出了貢獻。
壓痛儀的主要特點
· 提供三種測試量程250g500g750g
· 簡單可靠無需校準!
· 標準為砝碼測試型號可根據需要選擇數字顯示型號;
· 提供小鼠專用型號測量更準確;
· 1960年代以來的經典方法發表論文數百篇!
型號37215型
· 爪子放置在帶有圓形的錐形推動器下方的小底座上;
· 操作人員按下踏板開關壓力由小到大施加到動物的爪子上;
· 力以恒定速率增加使得測試具備很好的可重復性;
· 動物感受到疼痛時會產生躲避反應;
· 松開踏板開關壓力立即停止;
· 在以10g為步進單位施加力;
· 采用低壓同步電機符合CE規則;
· 根據需要可選擇小鼠專用的型號;
· 經典的砝碼款壓痛儀數字模塊相結合可升級為數顯型壓痛儀;
· 數顯型號更容易記錄數據和讀取數據;
· 傳統款式和數顯款式采用箱體的測試結構測量數據一致;
· 數字顯示器采用模塊化設計可以對傳統款式進行升級;

37215型壓痛儀的主要規格
· 電源115或230V50/60Hz
· 功率15W
· 操控方式踏板開關
· 尺寸40 x 16 x 14cm
· 重量2.1Kg
型號和測試量程
· 37215大鼠小鼠通用型250g500g750g
· 37216小鼠型號125g250g375g
壓力模塊
參考文獻
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medicine vol. 28,9 (2022)1813-1822. doi:10.1038/s41591-022-01956-3
2.Bosse, Gabriel D et al. “The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder." The Journal of clinical
investigation vol. 131,10 (2021)e143990. doi:10.1172/JCI143990
3.Bang, Sangsu et al. “GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain." The Journal of clinical investigation vol. 128,8 (2018):
3568-3582. doi:10.1172/JCI99888
4.Goebel, Andreas et al. “Passive transfer of fibromyalgia symptoms from patients to mice." The Journal of clinical investigation vol. 131,13 (2021)e144201.
doi:10.1172/JCI144201
5.Sikandar, Shafaq et al. “Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain." Brain a journal of neurology vol. 141,4
(2018)1028-1039. doi:10.1093/brain/awy009
6.Vidal-Torres, Alba et al. “Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonismWLB-73502, an analgesic with improved efficacy and
safety profile compared to strong opioids." Acta pharmaceutica Sinica. B vol. 13,1 (2023)82-99. doi:10.1016/j.apsb.2022.09.018
7.Mousa, Shaaban A et al. “Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain
areas." Journal of neuroinflammation vol. 19,1 148. 15 Jun. 2022, doi:10.1186/s12974-022-02498-8
8.Zhou, Danli et al. “Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain." Journal of
neuroinflammation vol. 16,1 83. 11 Apr. 2019, doi:10.1186/s12974-019-1476-6
9.Wang, Wenying et al. “Exchange factor directly activated by cAMP-PKCε signalling mediates chronic morphine-induced expression of purine P2X3 receptor in rat
dorsal root ganglia." British journal of pharmacology vol. 175,10 (2018)1760-1769. doi:10.1111/bph.14191
10.Sala, Emanuele et al. “Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent
models." British journal of pharmacology vol. 177,14 (2020)3291-3308. doi:10.1111/bph.15049
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